Renue By Science

LIPO NAD+ Complete is designed to deliver the most potent dose of NAD+, NMN & NR via nanoscale liposomes to increase your body’s NAD+ levels. While there is a lot of uncertainty about the pathways NAD⁺ and NAD⁺ precursors take in the body, we do know that there are differences between them, and they have affinity for different tissues. We believe the most effective protocol to increase NAD⁺ is through targeting all of these pathways. Three-In-One Capsule We provide all three in one capsule to better address all parts of the body that may benefit from replenishing NAD⁺ levels. Learn More About Liposomal Delivery Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach. The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵ Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. RESEARCH ON LIPOSOMES FOR INCREASED BIOAVAILABILITY With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is. For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.Hence the study below shows it is about 10x more bioavailable. Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin. Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce. "Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." - International Journal of Nanomedicine, Liposomes As Nanomedical Devices Depending on the molecule, with Liposomes 90% of the ingredients can typically make it to the bloodstream.   Many common supplements  are digested by enzymes and bacteria in the stomach.  If they make it past the intestines to the liver, they are seen as a foriegn body and are mostly filtered out. Studies show nearly all NAD+ boosters do not escape the liver at all, but are converted to NAM which is released into the bloodstream. Liposomes protect ingredients from digestion. As they are composed of phospholipds that are very similar to the membrane of every cell in our body, they are seen as native and are not filtered out by the liver, which released them intact into the bloodstream where they dissolve after a few hours and release the payload where it can be taken up by cells.   The Benefits of Liposomes More Economical - Manufacturing liposomes does add cost to the finished product, however, a 2x increase in cost is vastly outweighed by the 5-20x or greater increase in effectiveness of liposomal delivery. More Effective - Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you're taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely.  Liposomes deliver much higher quantities of the target molecules to the bloodstream. Safer - Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages.  The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished. The phospholipids in the liposomes closely resemble the structure of your cell membranes, and as a result the body recognizes them as safe and friendly substances which are biocompatible. About Our Liposomal Capsules Our LIPO Caps™ are used in our liposomal capsule products. The process involves encapsulating nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It’s a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body. This ensures maximum bioavailability and stability, protecting the ingredients against degradation. This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. ⑶ We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity. About Our Lipo Gel Products LIPO Gel products are ideal for people who have trouble swallowing pills and prefer a liquid gel. Just put two pumps under the tongue and let it absorb for 30-60 seconds before swallowing. If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible. The liposomes are derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.  

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